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A broader mechanistic review by Seiwerth and colleagues in Current Pharmaceutical Design laid out how BPC-157 seems to borrow the same angiogenic and growth-factor pathways the body uses to heal the gut, and apply them to tendon, ligament, muscle, and bone (Seiwerth et al., 2018)

Epigastric pain, early satiety, and gastroesophageal reflux are common initial symptoms of TD and gastrointestinal beriberi (19, 70)

J Exp Med 173:699703 Sato H, Tamba M, Ishii T, Bannai S (1999) Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins

7 Final remarks Recognizing the importance of estrogen in skin homeostasis and repair presents an opportunity to develop innovative therapies that harness estrogens beneficial effects while minimizing systemic risks