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The widely used human in vitro model is the THP-1 cell line, which is derived from leukemic monocytes and can be differentiated into macrophages

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The formation of focal adhesions can be triggered by the depolymerimerization of microtubules, which activate tyrosine phosphorylation and the Rho GTPase, leading to enhanced integrin activation, the recruitment of specific adhesion complex components, and the assembly of focal adhesions [68,69,70]