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Colonization occurs primarily through competitive adhesion, whereby probiotic adhesinsincluding mucus-binding proteins (MUBs), the surface-layer protein SlpA, and the pilus-tip adhesin SpaCbind with high affinity to epithelial receptors or mucins, thereby spatially excluding pathogenic bacteria such as enteropathogenic Escherichia coli and Salmonella (Roos and Jonsson, 2002