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The vitamin is then transferred to TC2, which serves as the circulating plasma transporter, hereditary defects in the production of TC2 and its receptor may produce functional deficiencies in B 12 and infantile megaloblastic anemia, and abnormal B 12 related biochemistry, even in some cases with normal blood B 12 levels

In some physiological or developmental settings, DIO3 aids in hormone regulation, avoiding hyperthyroid conditions [34]

The authors also noted that use of Percoll gave much inferior recoveries and purity of parietal cells and also stimulated acid and cAMP secretion by gastric cells