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Moreover, the forbearance of transgenic lines toward different abiotic stresses such as cold, drought, salt, and heavy metals affirms its role in stress tolerance

More recent clinical trials have found no difference in comparison to a placebo (Javed et al., 2015)

Concurrently, NAD + depletion, exacerbated by poly(ADP-ribose) polymerase-1 (PARP-1) hyperactivation, cripples sirtuin activity, impairing mitochondrial biogenesis via peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1) dysregulation and reducing antioxidant defense through Forkhead box O (FOXO) signaling