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DN is pathologically characterized by mesangial matrix thickening, progressive destruction of glomerular and tubulointerstitial, and loss of functioning glomeruli, ultimately leading to chronic renal failure [138, 139]

Therefore, the most important function of GPX1-4 is to prevent oxidative stress by catalyzing the reduction of H 2 O 2 or organic hydroperoxides

Joshi DC, Chavan MB, Gurow K, Gupta M, Dhaliwal JS, Ming LC (2025) The role of mitochondrial dysfunction in Huntingtons disease: implications for therapeutic targeting