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Acknowledgements The authors are very thankful to the Director, CSIR-Central Drug Research Institute, Lucknow, U.P., India, for the constant encouragement and financial support

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Effects of two-year vitamin B12 and folic acid supplementation on depressive symptoms and quality of life in older adults with elevated homocysteine concentrations: additional results from the B-PROOF study, an RCT

On the contrary, alterations in the C-terminal seemed less critical for activity and for instance a deletion of the C-terminal phenylalanine residue of 1 had only a minor impact and the binding affinity was essentially maintained (Sardinia et al., 1993