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The three main populations that should avoid supplementation are: People who are pregnant or breastfeeding Currently, there isn't enough research to determine whether glutathione supplementation is appropriate for people who are pregnant or breastfeeding

Shanmugam G, Challa AK, Litovsky SH, Devarajan A, Wang D, Jones DP, et al

Opitac The researchers behind a 2014 in vivo/ex vivo study on mice found that 10mg of Opitac-branded glutathione (around 80mg for an 80kg/176lb human) could be transported across epithelial cells in the intestines

A randomized controlled trial of metformin on left ventricular hypertrophy in patients with coronary artery disease without diabetes: the MET-REMODEL trial