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These alterations not only extend its duration of action but also enable IGF-1 LR3 to circumvent binding with IGF-binding proteins, which typically impede the biological availability and efficacy of IGF-1

doi: 10.1007/s12011-016-0768-2 93 StojsavljeviARovaninBJagodiJKrstiPaunoviIGavrovi-JankuloviMet al

You can use it both in the morning and in the evening