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These interesting results were confirmed by immunocytochemistry.9 This paradigm was recently reexamined and expanded in immature castrated rats treated with high and medium doses of either T accompanied by finasteride to block DHT synthesis or DHT alone.15 After short (3 days) or longer (10 days) treatments, although castration did increase androgen binding in the penile cytosol, androgen replacement merely normalized AR concentrations to those found in intact animals of the same age and failed to decrease penile ARs below intact levels

& Iyer, P

Adding to the complexity, if the viral glycoprotein cross-seeds an endogenous brain protein, years later even the viral protein need not be present, as the run-away proteopathy would now involve only endogenous brain protein (s)

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