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3.3.3 The role of soluble uric acid in liver lipid metabolism and inflammatory injury ( Figure 5 ) Figure 5 In the liver, persistently elevated SUA under pathological conditions may disturb hepatocellular lipid homeostasis by interfering with energy-sensing pathways and autophagic clearance mechanisms

OA is a pathological change thought to be due to chondrocyte hypoxia, mitochondrial dysfunction, and oxidative stress, and previous studies have demonstrated that HK2 plays an important role in chondrocyte-induced glucose metabolism reorganization in these pathological changes through its association with voltage-dependent anion channels

Population-based evidence has shown that the incidences of AD and dementia are lower than expected in aging individuals with a history of gout [111]

Human cytomegalovirus mRNA-1647 vaccine candidate elicits potent and broad neutralization and higher antibody-dependent cellular cytotoxicity responses than the gB/MF59 vaccine