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doi:10.1038/nrneurol.2016.12 84

Enzyme Induction Some of the chemically dissimilar P450 substrate drugs, on repeated administration, induce P450 expression by enhancing the rate of its synthesis or reducing its rate of degradation ( Table 42 )

This suggests that NAD+ repletion can have metabolic benefits in humans, though the magnitude depends on baseline NAD+ status and the specific precursor used