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Mitochondria-targeted nitroxides, XJB-5-131 and JP-039 were shown effective in preventive ferroptotic cell death in HT-1080 fibrosarcoma cells, BJeLR cells and panc-1 cells [31]

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This results in the accumulation of damaged mitochondria, thereby establishing a vicious cycle in which mitochondrial damage leads to increased ROS, which in turn promotes ferroptosis

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