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The more you've got, the more wired you're going to feel, almost like your body is telling you, "Alert
Lineage-negative cells were enriched using the lineage cell depletion kit (Miltenyi Biotec, 130-110-470), differentiated in the presence of 20 ng ml 1 M-CSF (PeproTech, 315-02) for 3 days, treated with 10 g ml 1 -glucan or PBS for 24 h, cultured in the presence of M-CSF for 3 days, induced with 10 ng ml 1 LPS for 24 h before the medium was collected for quantification of cytokines
From a pharmacological safety perspective, the adverse effect profile of retatrutide based on Phase 1 and Phase 2 clinical trial data (including the NEJM 2023 Phase 2 trial) includes: Gastrointestinal effects: Nausea, vomiting, diarrhoea, and constipation (the most commonly reported side effects in trial participants) Injection site reactions: Redness, swelling, or discomfort at the injection site Cardiovascular effects: Increases in heart rate have been observed in trial participants [21] [22] Hypoglycaemia: Particularly relevant in individuals with diabetes or those taking insulin, sulfonylureas, or other glucose-lowering agents Potential thyroid effects: GLP-1 receptor agonists have been associated with thyroid C-cell changes in rodent studies
