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A 2018 Cell Metabolism follow-up found that under metabolic stress, MOTS-c actually moves into the nucleus and helps regulate gene expression there, tying it into stress-response pathways (PMID 29983246) [4]

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The nine tissue systems now documented in the preclinical literature were not predicted by computational models or receptor-binding assays at the outset they were identified sequentially as researchers in different laboratories independently tested the compound against different experimental injury models and consistently found meaningful effects

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