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Designing prodrugs that are inactive in the systemic circulation but are selectively activated by enzymes overexpressed in diseased tissues (e.g., cathepsins and matrix metalloproteinases) allows for the localized release of active copper-modulating agents, thereby minimizing off-target effects [257]

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Evid-Based Complement Alternat Med 1:413808 Qiao Y, Gu J, Yu M, Chi Y, Ma Y (2024) Comparative efficacy and safety of monoclonal antibodies for cognitive decline in patients with Alzheimers disease: a systematic review and network meta-analysis

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