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Neurotoxicology, 2011

1 Introduction Acute respiratory distress syndrome (ARDS) is a diffuse lung injury caused by intrapulmonary and extrapulmonary factors in a short period, histologically characterized by diffuse alveolar damage, including pulmonary edema, hyaline membrane formation, alveolar hemorrhage and inflammation ( Sepsis is a systemic inflammatory reaction caused by a maladjusted response to infection induced by pathogenic microorganisms ( 2 ARDS heterogeneity The clinical, physiological, biological and imaging manifestations of ARDS are highly heterogeneous