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Although the role of bombesins in modulating mucus secretion or muc5AC/muc5B regulation in COPD is unknown, given that bombesins are increased in COPD [193] and muc5B is also increased [188], then it is possible that either a direct or indirect relationship between bombesin signaling and muc5B expression exists

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In contrast, the pS-MIP approach showed no obvious preference for acidic amino acid residues but instead showed a preference for a distinct hydrophobic SP-motif

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