The peptide molecule itself is large and the skin barrier limits penetration
Description (Sterile Lipotropic and B-Complex Injectable for Fat Metabolism, Liver Health, and Energy Support) Targeted Lipotropic Formula with Vitamin B12 for Weight Management and Metabolic Optimization MIC + B12 Injection 30 mL is a sterile, preservative-free compounded formula combining the powerful fat-metabolizing effects of Methionine, Inositol, and Choline (MIC) with the metabolic and neurological support of Vitamin B12 (as methylcobalamin)
Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O
195,196,197 At the cellular level, this translates into a massive increase in cytoplasmic Na + concentration, membrane depolarisation and opening of voltage-gated Ca 2+ channels, which in turn promotes massive release of glutamate that results in even large depolarisation enlarging Na + and Ca 2+ influx thus completing the vicious circle of excitotoxic damage, as Ca 2+ overload triggers necrotic cell death
