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Of these, four were excluded before any attempts at pump implantation (phase 1): one before the initial workup died suddenly owing to poor cardiac status, and three were excluded during the initial workup (owing to mild fluctuations, psychosis during the acute l-dopa administration test and benign brain tumor)

However, newer compounds like Dihexa and PE-22-28 have limited human safety data

The benefits of N-acetylcysteine were seen primarily in patients with early-stage disease and coma grade I or II (52% vs 30% transplant-free survival) but not in those with advanced coma grade (III or IV) at randomization

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