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The phenotypic manifestations of ASD are largely heterogeneous, which might be explained by complex interaction of genetic susceptibility with different risk factors, leading to an individual path of developing ASD in each person

In this review, we first introduce metabolic pathways that enable glutamine to respond to diverse cellular needs and then discuss the metabolic link by which glutamine-derived metabolites may affect cellular metabolic processes, including NEAA synthesis, epigenetic modifications, and hypoxia adaptation

Dietary Glycine Is Rate-Limiting for Glutathione Synthesis and May Have Broad Potential for Health Protection

10.1073/pnas.58.2.719 567 StuchfieldD.BarranP