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"These findings highlight a large gap in our understanding of how continued tobacco use might influence drug metabolism, therapeutic response and long-term outcomes," the experts said, adding that the issue is most pressing in low and middle-income countries with 80 per cent of tobacco users

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This two-phase sleep therefore offered a little time within the night itself

However, industry efforts to respond to the health threat of smoking by promoting filtered and so-called light cigarettes tended to counteract the effects of antismoking messages and to sustain smoking by those who smoked the most heavily