thioredoxin glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target Involvement of glutaredoxin-1 and thioredoxin-1

doi: 10.1038/ni.2166 529 SmithMBHaneyEMcDonaghMPappasMDaegesMWassonNet al

Activators At the transcriptional level, NFE2L2 gene is induced by several transcription factors, including the aryl hydrocarbon receptor (AhR) in response to environmental pollutants like polycyclic aromatic hydrocarbons, breast cancer susceptibility gene 1 (BRCA1) in response to xenobiotic stress, and the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) in response to inflammatory stimuli

Antibiotics with antibiofilm activity rifampicin and beyond

The ENaC channel is composed of three subunits (, , and ) that are encoded by three distinct genes that are member of the large family of sodium ion channels