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Mean weight loss over 46 weeks, at the highest dose of 4.8 mg OD, was 14.9% (vs

Globally, nearly 250,000 cases occur each year, and without timely intervention, the mortality rate approaches 100% (Iyer et al., 2021)

Even though some of these drugs have advanced to clinical trials (as indicated in Table 2), these limitations severely constrain their clinical development progress

The results allowed for describing time courses of five known compounds, namely catechin, taxifolin, caffeic acid, ferulic acid and the gut microbial metabolite 5-(3,4-dihydroxyphenyl)--valerolactone (see also section 6.1 Pre-systemic metabolism: role of gut microbiota)