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In obesity, NNMT activity is unusually high in fat cells, which means a lot of nicotinamide gets thrown out before it can be turned into NAD+
PubMed Philp, D., Badamchian, M., Scheremeta, B., Nguyen, M., Goldstein, A.L., & Kleinman, H.K
Here are seven reasons why you may have a B12 deficiency and could benefit from a B12 supplement/injection: You are older as it becomes harder for the body to absorb B12 as we get older You drink heavily as alcohol can hinder the bodys ability to absorb B12 You had weight loss surgery or another operation that removed part of your stomach You are a vegetarian and dont eat enough eggs or dairy products to meet your vitamin B12 needs You have a Crohns disease , celiac disease or any condition that affects your small intestines You have an immune system disorder such as Graves disease or lupus You take certain heartburn medications such as Neium and Prilosec