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doi: 10.1038/nrm2256 36 RazaMHSirajSArshadAWaheedUAldakheelFAlduraywishSet al

In reverse mode NET causes an efflux of the cytoplasmic pool of presynaptic norepinephrine into the synaptic cleft, where it can activate postsynaptic -1 and -1 receptors to elevate systemic vascular resistance and stimulate cardiac output (Vansal & Feller 1999