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It has been traditionally thought that exogenous GABA (i.e., taken as a supplement) does not cross the bloodbrain barrier, but data obtained from more recent research (2010s) in rats describes the notion as being unclear

Taken together, the literature indicates that while both CHAC1 and CHAC2 participate in related biological processes, their different structural and regulatory properties suggest complementary rather than redundant functions

RNA nanoparticle as a vector for targeted siRNA delivery into glioblastoma mouse model