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For eczema specifically, the disrupted skin barrier actually allows better peptide penetration than intact skin would, which is an ironic advantage of the condition

[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Lamers M.M., Haagmans B.L

For these reasons, PregS more closely resembles the characteristics of classical neurotransmitters, such as acetylcholine, in which the parent molecule bears a full positive charge and is active only at an extracellularly directed recognition site while the immediate breakdown products (choline + acetic acid) are inactive

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