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Although we found evidence suggesting an association between SHS exposure and these other investigated health outcomes, the associations did not achieve statistical significance when using the BPRF approach to capture uncertainty that accounts for between-study heterogeneity

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These results can guide treatment efforts on smokeless tobacco by targeting the treatment for alcohol use disorder among all smokeless tobacco users, the treatment for panic disorder, specific phobia, and inhalant use disorder among exclusive chewing tobacco users, as well as the treatment for cannabis use disorder among exclusive snuff users