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Contraindications for Ozone Therapy Ozone therapy is not recommended for individuals with the following conditions: Hyperthyroidism (Graves disease) G6PD deficiency Thrombocytopenia (low platelet count) Hemochromatosis (excess iron) Pregnancy Alcohol intoxication Cardiovascular instability Safety and When to Call the Office After your IV or ozone therapy session, contact our office immediately if you experience any of the following: Fever Swelling or warmth at the injection site Red streaks extending from the injection site Drainage or discharge Joint immobility or increasing pain If your symptoms worsen, please seek emergency medical care