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More broadly, systematic multigenerational studies will be required to assess the stability, inheritance, and expression dynamics of R2-mediated insertions and to define genomic contexts that support durable Pol II-driven transgene expression

2 Department of Pulmonary and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, Peoples Republic of China Correspondence: Yi-Qing Qu Department of Pulmonary and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, Peoples Republic of China Tel +86 531 8216 9335 Fax +86 531 8296 7544 Email [email protected] Abstract: COPD is a common disease of the respiratory system

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