l carnitine and tmao biosynthesis. L-carnitine choline are derived from the diet The process of TMA/TMAO's metabolism

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(2024, CNS Neuroscience & Therapeutics ) confirmed ARA-290 provided neuroprotective effects in a mouse MCAO (middle cerebral artery occlusion) model comparable to full-length EPO, significantly reducing neuronal apoptosis and inflammatory cytokines, confirmed to act via CR without stimulating erythropoiesis Blood-brain barrier (BBB) penetration confirmed in pre-clinical studies

The proposed mechanism involves inhibiting tyrosinase, an enzyme central to melanin synthesis

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