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Moreover, patients with PD were reported to have lower peripheral blood levels of t--Syn, which was inversely linked to their motor impairments ( -Syn concentration in the control group was much lower than that of the PD group, whereas it was significantly higher in the patients with multiple system atrophy (MSA) ( -Syn stimulated cells, PD patients were detected with more IL-1 and IL-6 and less IL-10 than healthy controls, indicating an imbalance in the pro-inflammatory and anti-inflammatory cytokines in PD-associated neuroinflammation ( -Syn, anti-proteinase K (PKres) -Syn, and p--Syn (PSer 129), was a strong indicator of differentiating PD patients from controls, with an area under the curve (AUC) of 0.81