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It has been under research for over 50 years, with consistent findings of excellent tolerability in both topical and injectable applications

Keywords such as "brain support peptides, "cognitive wellness peptides, and "natural neuro-regeneration are beginning to appear more frequently in content tied to holistic wellness and longevity

doi: 10.1007/s11064-007-9377-y

So people at greatest risk for deficiency include those with low stomach acid (e.g., older adults and people on proton pump inhibitors or antacids) or low IF production (known as pernicious anemia), people on medications that interfere with B12 absorption (such as metformin), people who have had gastric surgery, those with GI conditions that impair nutrient absorption (like celiac or Crohn's disease), and people on vegan and vegetarian diets