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The ROS generated from aerobic respiration caused a cumulative oxidative damage in macromolecules, including lipids, DNA, and proteins, which subsequently lead to cells death (Scheibye-Knudsen et al., 2015), and affect the healthspan of numerous principal organ systems (Dai et al., 2014)

Cellular capacities for ROS elimination are limited in Nrf2 -null mice ( Nrf2 -null mice tend to spontaneously develop various inflammatory disorders, including glomerulonephritis, immune-mediated hemolytic anemia, and multi-organ autoimmune inflammation (Yoh et al., 2001

If side effects develop, discontinue treatment and reevaluate with a clinician

These refer to the activity of activation factors