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Insufficient maternal nutrition, especially during critical periods of embryonic and fetal development, manifests as an overall elevation of ovarian OS, which, along with impaired mitochondrial antioxidant defenses, may be responsible for these significantly decreased follicle numbers and resultant growth impediment of offspring [275]
Note: The above statements have not been evaluated by the Food and Drug Administration
In addition to the above mechanism, adsorptive-mediated transcytosis (AMT) is the principal way used for macromolecular transport, which is based on electrostatic interactions between cationic molecules and anionic microdomains present on the membrane of the brain capillary endothelial cells (Lu, 2012)
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