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When evidence emerged about its rapid (within several hours) antidepressant effects (23), ketamine revolutionized the landscape as there was desperate need for urgent relief of suicidal crises and faster restoration of functioning, thereby providing a respite on economic and social burdens of treatment-resistant depression

This complex has been shown in experimental literature to interact with multiple signaling pathways related to tissue remodeling and gene regulation

10.1016/j.ejphar.2012.01.010 Summary Keywords acetaminophen, phytic acid, iron, SIRT -1, CYP2E1 , liver Citation Hassan HM, Abdel-Halim NHM, El-Shenbaby I, Helmy MA, Hammad MO, Habotta OA, El Nashar EM, Alghamdi MA, Aldahhan RA, Al-Khater KM, Almohaywi B and Farrag EAE (2024) Phytic acid attenuates acetaminophen-induced hepatotoxicity via modulating iron-mediated oxidative stress and SIRT-1 expression in mice