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however, to the extent patients were treated with other treatments before SPEVIGO, we question whether it may be appropriate to remove some portion of these charges to avoid inappropriately inflating the average charge per case

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Fistuals are common in inflammatory diseases of the GI tract, such as Crohns disease and ulcerative colitis

Pro-inflammatory cytokines, particularly IL-1, TNF-, and IL-6, are key mediators that stimulate chondrocytes to upregulate degradative enzymes such as matrix metalloproteinases (MMP-1, MMP-3, MMP-13) and aggrecanases (ADAMTS-4 and ADAMTS-5)