Deborah Levine: Nothing to disclose E-Posters - RECOVERY, REHABILITATION AND OUTCOME 03.00 - RECOVERY, REHABILITATION AND OUTCOME - 03.03 - PROGNOSIS AND OUTCOME AFTER STROKE P2225 - ESOC25-874 USE OF ANTIDEPRESSANTS IN YOUNG STROKE PATIENTS: INSIGHTS FROM A MULTICENTER STUDY Jenna Broman 1 , Daniela Pinter 2 , Simon Fandler-Hfler, Bettina von Sarnowski 3 , Mohamed Elmegiri 4 , Thomas Gattringer 5,6 , Robert Malinowski 3 , Juha Martola 4 , Stefan Ropele, Ulf Schminke 3 , Turgut Tatlisumak 1,7 , Christian Enzinger, Karoliina Aarnio 1 , Jukka Putaala 1 1 Department of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland, 2 Department of Neurology, Research Unit for Neuronal Plasticity and Repair, Medical University of Graz, Graz, Austria, 3 Department of Neurology, University Medicine Greifswald, Greifswald, Germany, 4 Department of Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland, 5 Department of Neurology, Medical University of Graz, Graz, Austria, 6 Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria, 7 Department of Clinical Neuroscience, Institute of Neurosciences and Physiology, Sahlgrenska Academy at University of Gothenburg & Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden Background and Aims: Depression after stroke is common and occurs in approximately one-third of patients, potentially affecting their quality of life and worsening the outcome
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
The actin-sequestration mechanism of TB-500 is not well-suited to cytoprotective questions of this type
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