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258 billion in 2016 (21)

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No cigarette advertising shall be used which refers to the removal or the reduction of any ingredient in the mainstream smoke of a cigarette, except that it shall be permissible to make a reppresentation as to the quantity of an ingredient present in the mainstream smoke or as to the removal in toto of an ingredient from the mainstream smoke, or as to the absence of an ingredient normally present in the mainstream smoke, if: (a) The Administrator shall have determined that such representation is significant in terms of health and is based on adequate relevant and valid scientific data