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Antineutrophil cytoplasmic antibody (ANCA) positive cases are usually connected with deleterious immune system-mediated side effects such as vasculitis and autoimmune hepatitis induced by antithyroid medications.62,63 The presence of other autoantibodies such as preneuclear antineutrophil cytoplasmic antibody and antimyeloperoxidase antineutrophil cytoplasmic antibody all indicate that the immune system might be involved in antithyroid drugs side effects.64,65 "Hapten hypothesis" is an intriguing theory for immune-mediated drugs-induced hepatotoxicity.66 According to this hypothesis, reactive intermediates of different drugs, undergo covalent binding with different cellular proteins