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This Wnt-axis activity helps explain several otherwise disconnected observations why GHK-Cu promotes hair regrowth, why it extends fibroblast proliferative lifespan, and why it appears to reset certain senescence markers in aged skin cells

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Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness