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On the other hand, methimazole should be administered cautiously in older persons with an appropriate dose, not only because of the concern for higher rate of agranulocytosis,87 but also probably because of more susceptibility of these patients to the hepatic injury induced by this drug.88 In conclusion, no clear and direct relationship between patients' age and antithyroid agents-induced hepatotoxicity has been founded yet, except for a higher rate of PTU-induced liver damage in pediatrics by an unknown mechanism(s)
[5] If you're taking oral medications, be sure to only take the dosage on the label
2006, 60-90 mcg/kg doses were well tolerated in men aged 20-40, and most effects are dose-dependent, typically resolving within 7-28 days of dose reduction or discontinuation
To get a clearer picture of this clinical trial process, heres a simple breakdown of how they typically go: Phase 1: A small group of volunteers tries the medication so researchers can check basic safety and figure out early dosing
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