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Furthermore, existing research has largely focused on transport mechanisms under physiological conditions, while in pathological contextssuch as impaired blood-brain barrier integrity or chronic inflammatory microenvironmentsthese transport patterns may undergo significant reprogramming, with regulatory networks likely far more complex than current models suggest

found that oxidative stress changed the redox potential of the breast, leading to drastic changes in the DNA base lesions, which are conducive to oxidative conditions and breast cancer formation [64]

7 , a020412 (2015)

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