188 LCN2 inhibits ferroptosis by enhancing GPX4 and SLC7A11 expression and reducing intracellular iron levels, and LCN2 overexpression in colon cancer cells leads to resistance to 5-fluorouracil (5-FU) by inhibiting ferroptosis
For CIDP, evidence is also emerging that patients previously maintained on IVIg treatment may undergo disease worsening upon switching to FcRn antagonists, underlining the fact that other disease drivers than solely auto-Abs are also vital aspects of pathophysiology in at least certain patients with CIDP [265, 401, 402]
Biochim Biophys Acta 1807:989998 Pogny M, von Rad U, Grn S, Dong A, Pintye A, Simoneau P, Bahnweg G, Kiss L, Barna B, Durner J (2009) Dual roles of reactive oxygen species and NADPH oxidase RBOHD in an Arabidopsis- Alternaria pathosystem
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