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In addition, a study conducted in BV2 murine microglia cells, which served as a representative cell specimen for brain microglia, showed that the upregulation of antioxidant/detoxification proteins by SFN was associated with enhanced resistance of microglial cells to heat-induced toxicity and removal of ROS during microglial cell activation (90)

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Additionally, the upregulation of the amyloid precursor protein, located on chromosome 21, leads to the accumulation of A plaques, which is associated with the development of AD and, in many instances, cerebral amyloid angiopathy (Nunomura et al

Chen H, Lu C, Liu H, Wang M, Zhao H, Yan Y, et al