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When an oxidative stressor or electrophile interacts with the Keap1-Nrf2 complex, it allows for the release and subsequent nuclear accumulation of Nrf2 through a complex process of ubiquitination-inhibition, thus triggering an anti-stress response by the cell

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This endogenous peptide encoded within the mitochondrial genome has been studied in metabolic and exercise physiology research models examining AMPK activation, glucose homeostasis, and fatty acid oxidation pathways

Carnitine and its derivatives in cardiovascular disease 31