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Heat-Not-Burn Tobacco, Heated Tobacco Products, Next Generation Products, Public Health, Risk Reduction, Smoking, Tobacco Harm Reduction, Tobacco Heating Products aHTPs: Aerosol Heated Tobacco Products AIx: Augmentation Index ARE: Antioxidant Response Element BAT: British American Tobacco cHTPs: Carbon Heated Tobacco Products COPD: Chronic Obstructive Pulmonary Disease CORESTA: Cooperation Centre for Scientific Research Relative to Tobacco ECG: Electrocardiogram EHCSS: Electrically Heated Cigarette Smoking System eHTPs: Electrically Heated Tobacco Products ETS: Environmental Tobacco Smoke EVP: e-vapour product FDA: Food and Drug Administration FEF: Forced Expiratory Flow FVC: Forced Vital Capacity HCS: High Content Screening HPHCs: Harmful and Potentially Harmful Constituents IAQ: Indoor Air Quality JTI: Japan Tobacco International KT&G: Korea Tobacco and Ginseng MOE: Margin of Exposure NGPs: Next Generation Products PMI: Philip Morris International PWV: Pulse Wave Velocity QSU: Questionnaire of Smoking Urges THP: Tobacco Heating Product THS: Tobacco Heating System TPM: Total Particulate Matter TSNAs: Tobacco-Specific Nitrosamines The health effects associated with conventional cigarette smoking have been extensively documented by the public health and scientific communities (United States Surgeon General, 2010

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Prior to 1992, blood transfusion