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Upon transport into the axoplasm of sympathetic terminals, ephedrine utilizes the vesicular monoamine transporter 2 (VMAT2) to enter acidic storage vesicles in the readily releasable pool docked near the surface membrane (Costa et al, 2022)

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Human and canine patients with IVD degeneration can thus be used as a study population to investigate the mechanisms of degeneration and potential regenerative treatments, which is beneficial for both species and suits the 'One Health concept

After overnight incubation, medium was exchanged for RPMI supplemented with 10% FCS