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Therapeutic Effect of Berberine on Huntington's Disease Transgenic Mouse Model

101 In addition, hypoxia-induced lactylation of serine hydroxymethyltransferase 2 (SHMT2) upregulates its protein level, enhancing methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) expression and the stemness of esophageal squamous cell carcinoma cell lines, thus accelerating the malignant progression of esophageal cancer

In particular, we focus on the reciprocal effects of medications used to treat PD and GM composition, which is the research focus of the novel, cutting-edge subfield of pharmacogenomics called pharmacomicrobiomics [23]

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